Regulatory T cells, especially naturally arising CD25+ CD4+ Tregs, in which expression of the transcription factor forkhead box p3 occurs in the thymus, actively engage in the maintenance of immunological self-tolerance and immune homeostasis.
Regulatory T cells (Tregs) are specialized immune cells that help maintain balance in the immune system by suppressing overactivity and promoting tolerance to self-antigens. They develop in the thymus and express specific markers such as CD4 and FOXP3. Their key roles include preventing autoimmune diseases, minimizing inflammation after infections, and promoting immune tolerance.
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