Histamine is the substance that causes itching in response to allergens. Released during an allergic reaction, it binds to receptors in the skin, resulting in itching and other symptoms. Other substances released, like heparin, do not directly cause itching. ;
Histamine is the substance responsible for itching when released by the body in response to allergens. It interacts with receptors in the skin, leading to symptoms like itching and swelling. Other substances, such as heparin, do not cause itching directly.
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