Which type of mutation causes sickle cell anemia?

Sickle cell anemia is caused by a missense mutation in the HBB gene, leading to a single amino acid substitution. This mutation changes normal hemoglobin into hemoglobin S, which causes the characteristic sickling of red blood cells. Unlike silent mutations, the missense mutation significantly affects protein function. ;

Answered by GinnyAnswer | 2025-07-07